If you are making a very high output HHO Gen,
the one benefit I can see to using higher voltage is:
The amperage draw! Lower voltage means higher amperage.
Compared to higher voltage lower amperage.
Lower voltage higher amperage:
Bigger wires need, higher amperage rated controls IE: relays, fuse holders, connectors, PWMs....
Higher voltage lower amps:
smaller gauge wire, smaller relays, smaller fuse holders, smaller components for the PWM.............
Mother Nature educates all of us that are teachable. She's hardest on the ones who refuse to learn. Punishment is automatic, immediate, and without pity.